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M., Singh S

Funding This work did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors

A major obstacle to effective treatment is the inability of many neuroprotective agents to reach the brain at therapeutically relevant concentrations due to poor bioavailability and the restrictive nature of the bloodbrain barrier

Most gastrointestinal events were classified as mild to moderate, and the majority were transient, resolving within the first several weeks of treatment or after dose stabilization

These nutraceuticals have some mechanisms of action in common, including the inhibition of ACE, the enhancement of NO-mediated vasodilation, interactions with ion channels including the blocking of calcium channels and opening of potassium channels with consequent membrane hyperpolarization, anti-inflammatory effects with reductions in synthesis and release of pro-inflammatory cytokines, and enhancement of endogenous antioxidant actions exerted by different enzymes, such as SOD, GPx, and GSTP

MTT solution was added to each well, followed by incubation for 1 h at a final concentration of 5 mg/mL in 5% CO 2 at 37 C